Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its originArticle Published on 2022-12-012022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome beta-coronavirus Characteristics conducted conserved coronavirus disease Coronavirus-2 COVID-19 distribution Evenly-uneven Evidence Evolution Frequency functional furin cleavage Furin cleavage site (FCS) hypothese Hypothesis Invariant regions Mutation mutations pandemic Pandemics Protein question Region residue residues SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. Support the SARS-CoV-2 Transmissibility unique variants virulence virus [DOI] 10.1016/j.ijbiomac.2022.09.184 PMC 바로가기
Hyperbaric oxygen for treatment of long COVID-19 syndrome (HOT-LoCO): protocol for a randomised, placebo-controlled, double-blind, phase II clinical trialArticle Published on 2022-11-022022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] approved assessment baseline Blood Cardiology case sery chronic fatigue syndrome chronic inflammation clinical clinical trial cognitive collected common COVID-19 defined domain double-blind dysfunction Effect effective Efficacy endothelial function Ethics evaluate fatigue healthy subject hyperbaric oxygen hypothese immunology IMPROVE Inconclusive independent individual initial institutional review board Long malaise mechanism monitoring board oxygen Oxygen therapy pandemic Patient peer-reviewed performed physical placebo-controlled placebo-controlled clinical trial positive Potential treatment product protocol Quality of life Questionnaires randomised rehabilitation medicine respiratory medicine (see thoracic medicine) secondary endpoint suggested survey Swedish Symptom syndrome the primary endpoint Treatment Trial VASCULAR MEDICINE. [DOI] 10.1136/bmjopen-2022-061870 PMC 바로가기
An explanatory model of depressive symptoms from anxiety, post-traumatic stress, somatic symptoms, and symptom perception: the potential role of inflammatory markers in hospitalized COVID-19 patientsArticle Published on 2022-10-102022-11-15 Journal: BMC Psychiatry [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Analysis Anxiety anxiety symptom anxiety symptoms association back pain biological marker collected conducted COVID-19 COVID-19 pandemic cross-sectional demonstrated Depression depressive depressive symptom Depressive symptoms evaluate explain Factor highest hospital Hospitalized hospitalized COVID-19 patient hospitalized patient hypothese identify incidence individual Inflammation Inflammatory Inflammatory marker inflammatory markers Inflammatory response influence irritability marker mental health mental health problem NLR performed Peru post-traumatic Post-traumatic stress symptoms post-traumatic stress. predict Predictive Prevalence problem Psychological random Result Stress Symptom Symptoms variable vulnerable patient with COVID-19 [DOI] 10.1186/s12888-022-04277-4 PMC 바로가기
Functional associations between polymorphic regions of the human 3’IgH locus and COVID-19 disease인간 3'IgH 유전자좌의 다형성 영역과 COVID-19 질병 간의 기능적 연관성Article Published on 2022-09-052022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 변종, [키워드] age allele allelic Allelic polymorphisms Alpha association blood sample Blood samples Clinical outcome clinical outcomes Clinical severity collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients diffusion disease severity disequilibrium distribution DNA binding enhancer enhancer region ERα Estrogen Estrogen receptor alpha exhibited explain Genetic genetic background Genetic variant genetic variants genotyped SNP genotyped SNPs haplotypes heavy chain hospital hs1,2 enhancer. humans hypothese IgH locus immune response Immunoglobulin Infection Italy less linkage locus men MOST nine nucleotide Occurrence pandemic Pneumonia produced protective factor receptor Region SARS-COV-2 infection severe disease sex differences Sex-related differences significantly SNPs women [DOI] 10.1016/j.gene.2022.146698 PMC 바로가기 [Article Type] Article
Lipoprotein(a) during COVID-19 hospitalization: Thrombosis, inflammation, and mortalityResearch article Published on 2022-09-012022-10-05 Journal: Atherosclerosis [Category] SARS, 바이오마커, [키워드] 1.26 adjusted hazard ratio Biomarker C-reactive protein Coronavirus disease 2019 COVID-19 COVID-19 hospitalization COVID-19 patients CRP D-dimer death discharge elevated hazard ratio hospital hospital discharge hypothese Inflammation Inflammatory biomarker interleukin-6 Mortality multivariable outcome Patient procalcitonin proinflammatory prothrombotic Result SARS-CoV-2 survival tested thrombotic university vaccination with COVID-19 [DOI] 10.1016/j.atherosclerosis.2022.07.015 [Article Type] Research article
Origin of novel coronavirus causing COVID-19: A computational biology study using artificial intelligenceResearch article Published on 2022-09-012022-10-05 Journal: Machine Learning with Applications [Category] 변종, [키워드] AI Algorithm analysed Analysis artificial intelligence bat caused Cluster Clustering collected coronavirus genomes country COVID-19 COVID-19 virus death disease Evidence examined experiment genome sequence genomic genomic sequence global pandemic Host hypothese infected case machine learning Novel coronavirus origin pandemic pangolin pangolins provide recent Research SARS-CoV-2 SARS-CoV-2 genome Scientific community the SARS-CoV-2 virus whole genome [DOI] 10.1016/j.mlwa.2022.100328 [Article Type] Research article
Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesisArticle Published on 2022-08-242022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, 유전자 메커니즘, [키워드] Affect Alter antibodies antibody binding binding affinity calculated cells change changes changes in Characteristics complexes contagious COVID-19 pandemic distribution docking domain drug design electrostatic electrostatic interaction ENhance entry of SARS-CoV-2 epitope hACE2 HSPGs human Angiotensin-converting enzyme hypothese Hypothesis immune evasion Invasion involved molecular mechanism mutant Mutation mutations neutralizing antibody occurred omicron pathophysiological Point mutation positive Protein Proteoglycan RBD RBD mutation RBD mutations residue S protein S trimer SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 variants strain surface the RBD Therapies Vaccine development variant variant strain. viral fitness viral infectivity virulence virus virus receptor [DOI] 10.3389/fpubh.2022.952916 PMC 바로가기
The Acid Ceramidase Is a SARS-CoV-2 Host Factor산성 세라미다제는 SARS-CoV-2 숙주 인자입니다Article Published on 2022-08-152022-09-11 Journal: Cells [Category] SARS, 변종, [키워드] accelerated acid acid sphingomyelinase analysis biochemical ceramidase ceramide Ceramides COVID-19 pandemic deacidify described down-regulate Effects enrichment Factor Fluoxetine fluoxetine. genomic Host hypothese hypotheses infected cells inhibit inhibitor interfere Lower lysosomal mRNA mRNAs Omicron variants ORF3 Protein reduce Replication reported RNA SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variants shown specific acid Support therapeutic strategy transmission rates Treatment variant viral entry viral gene expression viral replication [DOI] 10.3390/cells11162532 PMC 바로가기 [Article Type] Article
How does age determine the development of human immune-mediated arthritis? Reviews Published on 2022-08-102022-10-05 Journal: Nature reviews. Rheumatology [Category] 유전자 메커니즘, 진단, [키워드] Adults Affect age Arthritis autoantibody children chronic inflammation contribute controls Critical determine develop disease driven by Drivers environmental exposure Epigenetic expand facilitate Factor Factors Genetic genetics hypothese immune immune system immune tolerance Immune-mediated individual Inflammation involved juvenile idiopathic arthritis maturation mechanism mechanisms microbial modulation Numerous Pathogenesis Patient Phenotypes pro-inflammatory similarity tolerogenic [DOI] 10.1038/s41584-022-00814-3 [Article Type] Reviews
Environmental influences on child health outcomes: cohorts of individuals born very preterm Reviews Published on 2022-08-102022-10-05 Journal: Pediatric Research [Category] 바이오마커, [키워드] Asthma can be used characterized Child Cohort complications condition developmental disorders Effect enrolled environmental exposure environmental factor Extensive Health hypothese Impact increased risk individual influence influences on mechanism obesity outcome outcomes positive Preterm birth Program provided question Research Research question risk social determinant study participant [DOI] 10.1038/s41390-022-02230-5 [Article Type] Reviews